Sex-frailty differences in aging mice: neuropathologies and therapeutic projections

MACARENA L. HERRERA; OSVALDO M. BASMADJIAN; LEANDRO G. CHAMPARINI; EUGENIA FALOMIR LOCKHART; FRANCO JUAN-CRUZ DOLCETTI; CLAUDIA BEATRIZ HEREÑÚ; MARÍA JOSÉ BELLINI

Carloz Paz

Congreso; XXXIV Reunión Anual SAN 2019; 2019

Sociedad Argentina de Investigación en Neurociencia

Sex-frailty differences in aging mice: neuropathologies and therapeutic projectionsIn the present study, we evaluate possible frailty predictors in older mice in a sex-specific manner. We also observe the effects of IGF-1 gene therapy and its correlation with the expression of these frailty and emotionality. In order to evaluate frailty index we employed two different approaches, we perform a frailty assessment through a 31-Item Clinical Frailty Index and through a Performance-Based Eight-Item Frailty Index. Both indexes are in concordance to evaluate sex differences, but they do not correlate when evaluating IGF-1 therapy effects. Moreover, to reduced test-to-test variability for measures of dependent variables, in this aging model we compared open field results across studies of sex and treatment evaluation using z-score normalization. Our data show that regular open field parameters submitted to Z-score normalization analysis could be a useful tool to identify sex differences in aging mice after growth factors therapies. Considering that gender is a factor that influences the incidence and/or nature of all major complex diseases, our work is one of the first ones that compares the use of different frailty indices calculations to identify sex differences and therapy efficiency in aging models, specifically by the use of noninvasive therapeutical strategies.