Hepatitis B Virus Genotype Distribution and Genotype-Specific BCP/preCore Substitutions in Acute and Chronic Infections in Argentina

GONZÁLEZ LÓPEZ LEDESMA MM; MOJSIEJCZUK LN; RODRIGO B; SEVIC I; MAMMANA L; GALDAME O; GADANO A; FAINBOIM H; CAMPOS R; FLICHMAN D

PLOS ONE

PUBLIC LIBRARY SCIENCE

Lugar: San Francisco; Año: 2015

1932-6203

Aim In order to assess Hepatitis B Virus genotype (g) and subgenotype (sg) implications in the course of infection, 234 HBsAg positive patients in different infection stages were character-ized (66 acute infections, 63 HBeAg positive chronic infections and 105 anti-HBe positive chronic infections). Results Overall, sgA2 (17.9%), gD (20.9%), sgF1b (34.2%) and sgF4 (19.7%) were themost preva-lent. Subgenotype F1b was overrepresented in acute and chronic HBeAg infections (56.1%), whereas gD was themost frequent (40.0%) in anti-HBe positive chronic infections. Among chronic infections, HBeAg positivity rates were 50.0, 12.5, 62.8 and 35.3% for sgA2, gD, sgF1b and sgF4, respectively (p