CD105 expression in cancer-associated fibroblasts: A biomarker for bone metastasis in early invasive ductal breast cancer patients

MARÍA B. GIORELLO; LEANDRO M. MARTINEZ; FRANCISCO R. BORZONE; MARÍA D. PADÍN; MARÍA F. MORA; INA SEVIC; ALANIZ LAURA; MARÍA D. CALCAGNO; HERNAN GARCIA-RIVELLO; ALEJANDRA WERNICKE; VIVIAN LABOVSKY; NORMA A. CHASSEING

Frontiers in Cell and Developmental Biology

Frontiers

Año: 2023 vol. 11

Bone metastasis is one of the causes that mainly decrease survival in patients with advanced breast cancer. Therefore, it is essential to find prognostic markers for the occurrence of this type of metastasis during the early stage of the disease. Currently, cancer-associated fibroblasts, which represent 80% of the fibroblasts present in the tumor microenvironment, are an interesting target for studying new biomarkers and developing alternative therapies.This study evaluated the prognostic significance of the CD105 expression in cancerassociated fibroblasts in early breast cancer patients. Immunohistochemistry was used to assess CD105 expression in invasive ductal breast carcinomas (n=342), analyzing its association with clinical and pathological characteristics. High CD105 expression in cancerassociated fibroblasts was associated with an increased risk of metastatic occurrence