Albendazole treatment in laying hens: Egg residues and its effects on fertility and hatchability

MORENO, LAURA; BISTOLETTI, MARIANA; FERNÁNDEZ, HECTOR; CANTÓN, LUCILA; CEBALLOS, LAURA; CANTÓN, CANDELA; LANUSSE, CARLOS; ÁLVAREZ, LUIS I.

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

WILEY-BLACKWELL PUBLISHING, INC

Año: 2018 vol. 41 p. 726 - 733

0140-7783

This work characterized the egg residual concentrations of albendazole (ABZ) and itssulphoxide (ABZSO) and sulphone (ABZSO2) metabolites and evaluated their effecton egg fertility and hatchability after ABZ treatments to laying hens. Seventy henswere allocated in groups: Group-1 was the control without treatment; Group-2 received a single ABZ oral dose (10 mg/kg); Group-3, -4 and -5 were treated with ABZin medicated feed over 7 days at 10, 40, or 80 mg kg−1 day−1, respectively. Eggs wereanalyzed to determine the ABZ/metabolite level by HPLC or subjected to incubationto evaluate the fertility and hatchability. Only ABZSO and ABZSO2 metabolites werequantified in egg after ABZ single oral administration with maximum concentrationsof 0.47 ± 0.08 and 0.30 ± 0.07 μg/ml, respectively. ABZ and its metabolites werefound in eggs after 7-day ABZ treatments. The egg residue exposure estimated asAUCs (areas under the concentration vs. time curve) were 100.5 (ABZ), 56.3 (ABZSO)and 141.3 μg hr g−1 (ABZSO2). ABZ administration did not affect the egg fertility atany dosages. Egg hatchability was not affected by ABZ treatment at 10 mg/kg inmedicated feed, but it decreased when the dose was 4?8 times higher. These resultsshould be considered when ABZ is used for deworming laying hens