PEDOT:Tosylate‐Polyamine‐Based Organic Electrochemical Transistors for High‐Performance Bioelectronics

FENOY, GONZALO E.; BILDERLING, CATALINA; KNOLL, WOLFGANG; AZZARONI, OMAR; MARMISOLLÉ, WALDEMAR A.

Advanced Electronic Materials

Wiley-VCH Verlag

Año: 2021 vol. 7

2199-160X

The construction of organic electrochemical transistors (OECTs) usingpoly(3,4-ethylenedioxythiophene):tosylate and polyallylamine hydrochloridecomposites as conducting channel material is presented. The regulation ofthe polyelectrolyte-to-conducting polymer proportion allows one to easily tuneboth electronic and ionic characteristics of the transistors, yielding deviceswith low threshold voltages while preserving high transconductance, whichis an essential requisite for the effective integration of OECTs with biologicalsystems. Also, the incorporation of the polyelectrolyte enhances the transientresponse of the OECTs during the ON/OFF switching, probably due toimproved ion transport. Furthermore, the integration of pH-sensitive aminomoieties not only improves the pH response of the transistors but also allowsfor the non-denaturing electrostatic anchoring of functional enzymes. As aproof-of-concept, acetylcholinesterase is electrostatically immobilized by takingadvantage of the NH2 moieties, and the OECTs-based sensors are able to successfullymonitor the neurotransmitter acetylcholine in the range 5?125 μm.