Administration of caseinomacropeptide-enriched extract to mice enhances the calcium content of femur in a low-calcium diet

BURNS, P.; BINETTI, A.; TORTI, P.; KULOZIK. U; FORZANI, L.; RENZULLI, P.; VINDEROLA, G.; REINHEIMER, J.

INTERNATIONAL DAIRY JOURNAL

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2014 vol. 44 p. 15 - 20

0958-6946

Caseinomacropeptide (CMP) is the 64 C-terminal amino acid residue of k-casein, formed by chymosincleavage during cheese manufacture. This study examined the effects of oral administration of a CMPenrichedextract (CMPEE), obtained from a local dairy plant, on the Ca content of mouse femurs. Animalsreceived low (0.1%, w/v), normal (0.5%, w/v) or high (1.2%, w/v) Ca diet for 3 or 8 weeks and CMPEEdiluted (1:10) in their drinking water. No significant differences in Ca content were observed in faeces,kidney, urine or blood serum compared with control animals. The oral administration of CMP to micesignificantly enhanced the Ca content in femur under a low-Ca diet model, especially during the period offull body development (3 weeks), in which case a significant 12% Ca increase was observed. Thesefindings pave the way for further studies aimed at supplementing infant food with industrially-obtainedCMP-enriched extract for enhanced bone health.©