BECAS
BIDART Juan Esteban
artículos
Título:
TLR activation, immune response and viral protection elicited in cattle by a commercial vaccine against Bovine Herpesvirus-1
Autor/es:
KORNUTA, CLAUDIA A.; CHEUQUEPÁN VALENZUELA, FELIPE; BIDART, JUAN ESTEBAN; SORIA, IVANA; GAMMELLA, MARIELA; QUATTROCCHI, VALERIA; HECKER, Y.; MOORE, DADIN P.; ROMERA, SONIA; MARIN, MAIA; ZAMORANO, PATRICIA; LANGELLOTTI, CECILIA
Revista:
VIROLOGY
Editorial:
ACADEMIC PRESS INC ELSEVIER SCIENCE
Referencias:
Año: 2022 vol. 566 p. 98 - 105
ISSN:
0042-6822
Resumen:
The innate and acquired immune response induced by a commercial inactivated vaccine against Bovine Herpesvirus-1 (BoHV-1) and protection conferred against the virus were analyzed in cattle. Vaccination induced high levels of BoHV-1 antibodies at 30, 60, and 90 days post-vaccination (dpv). IgG1 and IgG2 isotypes were detected at 90 dpv, as well as virus-neutralizing antibodies. An increase of anti-BoHV-1 IgG1 in nasal swabs was detected 6 days post-challenge in vaccinated animals. After viral challenge, lower virus excretion and lower clinical score were observed in vaccinated as compared to unvaccinated animals, as well as BoHV-1-specific proliferation of lymphocytes and production of IFNγ, TNFα, and IL-4. Downregulation of the expression of endosome Toll-like receptors 8?9 was detected after booster vaccination. This is the first thorough study of the immunity generated by a commercial vaccine against BoHV-1 in cattle.
