Effects of Corneal Crosslinking for Keratoconus Assessed with Anterior Segment Optical Coherence Tomography

FUENTES BONTHOUX FERNANDO; GALLETTI JEREMÍAS GASTÓN; TYTIUN ADRIANA; PFÖRTNER TOMÁS; CHIARADÍA PABLO

CUREUS

CUREUS

Año: 2012

2168-8184

Purpose: To report anterior segment optical coherence tomography (AS-OCT) findings in corneas of keratoconus patients treated with riboflavin-ultraviolet-A-light-induced crosslinking (CXL).Methods: Prospective, non-randomized, single-center clinical study that included 9 CXL-treated keratoconus eyes followed with corneal topography, specular microscopy and AS-OCT for 12 months.Results: Both reduction of keratometric values and corneal thinning were evidenced in CXL-treated eyes, whereas untreated fellow eyes showed topographic progression. Three structural changes were found with AS-OCT: increase of anterior (180 ± 20 μm) stroma reflectivity that peaked at six months; hyperreflective demarcation line in posterior stroma (365 ± 56 μm) that gradually reduced its intensity until becoming undetectable in 50% of the cases after 12 months; and incomplete secondary hyperreflective lines located at variable depths that gradually disappeared.Conclusions: AS-OCT is a useful tool for assessment of CXL results since it can detect quantitative and qualitative modifications induced by this treatment.