INVESTIGADORES
GALLETTI JeremÍas GastÓn
artículos
Título:
Improved Keratoconus Detection by Ocular Response Analyzer Testing after Consideration of Corneal Thickness as a Confounding Factor
Autor/es:
GALLETTI JEREMÍAS GASTÓN; PFÖRTNER TOMÁS; FUENTES BONTHOUX FERNANDO
Revista:
JOURNAL OF REFRACTIVE SURGERY - (Print)
Editorial:
SLACK INC
Referencias:
Año: 2012 vol. 28 p. 202 - 208
ISSN:
1081-597X
Resumen:
To compare corneal hysteresis (CH) and corneal resistance factor (CRF) between normal eyes and eyes with keratoconus correcting for the effect of central corneal thickness (CCT) and to estimate keratoconus detection sensitivity and specificity of these parameters. METHODS: Observational case series of 102 normal eyes (control group) and 77 eyes with keratoconus (keratoconus group). Examination included corneal topography, tomography, and biomechanical testing with the Ocular Response Analyzer (Reichert Technologies). The confounding effect of CCT was controlled by stratification (20-μm CCT intervals) and linear transformation. Receiver operating characteristic curves were used to identify optimal CH and CRF cutoff points for keratoconus detection. Main outcome measures were CCT, CH, CRF, and diagnostic performance of CH and CRF. RESULTS: Corneal hysteresis and CRF were positively correlated to CCT in both groups. In the control versus keratoconus group, CH was 9.79 ± 1.51 vs 8.49 ± 1.48 (P