Plasma C-reactive protein, apolipoprotein B and triglycerides/HDL-cholesterol ratio as cardiometabolic risk factors in adolescents with and without metabolic syndrome.

MUSSO, CARLA; GRAFFIGNA, MABEL; SOUTELO, JIMENA; HONFI, MARGARITA; LEDESMA, LAURA; MIKSZTOWICZ, VERONICA; MIGLIANO, MARTA; LITWAK, LEON; SINAY, ISAAC; BERG, GABRIELA

Praga, Checoslovaquia

Congreso; 45 th Annual Meeting of the European Association for the Study of Diabetes (EASD 2009).; 2009

Sociedad Europea de Diabetes

 PLASMA C-REACTIVE PROTEIN, APOLIPOPROTEIN B AND TRIGLYCERIDES/HDL-CHOLESTEROL  RATIO AS CARDIOMETABOLIC RISK FACTORS IN ADOLESCENTS WITH AND WITHOUT METABOLIC SYNDROME Dra. C Musso, Dra. M Graffigna Dra. J Soutelo, Dra. M Honfi, Dra. L Ledesma,  Dra V Miksztowicz, Dra. M Migliano, Dra. G Berg. Background: The prevalence of the metabolic syndrome (MS) has increased worldwide. That imposes a substantial risk for type 2 diabetes and  premature cardiovascular disease in adulthood.  However to date no unified criteria exist to asses risk or outcomes in children and adolescents. The objetive was to establish  the prevalence of MS and risk factors for cardiovascular disease in adolescents. Adolescents from a high school were studied (n=943), 429 females and 514 males, ages range  from 11 to 14 years old. Weight, height, Body mass index (BMI), waist circumference (WC), and blood pressure were determined in all patients. Glycemia, lipid and lipoprotein profile, lipoprotein B (Apo B) and high sensitivity C-reactive protein (hs-CRP) levels  were measured after an overnight fast of 12 hours. Triglycerides/HDL-Cholesterol ratio (TG/HDL) was calculated.. Metabolic Syndrome was diagnosed according to the NCEP: ATP III criteria modified by Cook et al. A parent or guardian gave consent for participation. The protocol was approved by the ethic committee of the University of Buenos Aires. Prevalence of metabolic syndrome was 5.45% in the male group and 1.63% in female group. MS group presented higher TG/HDL ratio  than those without MS, median (range): 3.58 (0.94-7.4) vs 1.38 (0.63-7.59), p<0.001; no differences in hs-CRP were observed between groups: 1.7 mg/L  (0.1-8.3) vs 1.20 mg/L (0.1-8), respectively.  Apo B (mean±SD) was 74.1 ± 6.3 mg/dl  in  MS group and 46 ± 15.7 mg/dl in those without MS (p= 0.001). TG/HDL ratio  positively correlated with  BMI (r=0.18, p <0.001), WC (r=0.24,p<0.001), and Apo B (r=0.24, p<0.001). Although no differences between groups were observed, hs-CRP correlated with WC (r=0.14, p<0.001) and BMI (r=0.17, p< 0.001). Even when prevalence of MS in our patients was low, in those patiens who had MS atherogenic lipoprotein parameters were higher. However the inflamatory marker was not different between groups.  The risk to develop cardiovascular disease was clearly higher in the group with MS than in the group without MS. These findings emphasize the importance to evaluate cardiovascular risk factors in adolescents to assess strategies to prevent future disease.