HORMONAL PROFILE AND INFLAMMATION MARKERS IN PROSTATE CANCER

FABRE, BIBIANA; GROSMAN, HALINA; MESCH, VIVIANA; LOPEZ, MIGUEL; MAZZA, OSVALDO; BERG, GABRIELA

RIO DE JANEIRO, BRASIL

Congreso; 13TH INTERNATIONAL CONGRESS OF ENDOCRINOLOGY; 2008

INTERNATIONAL SOCIETY OF ENDOCRINOLOGY

It has been described that several chronic diseases are linked to obesity, as cardiovascular disease, metabolic syndrome, diabetes and some types of cancer, especially hormone-dependent tumors like breast and prostate cancer (PCa). This tumor can be related to obesity and insulin-resistance (IR), which in turn should condition sex hormones profile. Their role in PCA prevalence is controversial. Meanwhile, citokines synthesized in adipose tissue also can modulate biological features of PCa. Objetives: -To evaluate sex hormones profile, inflammation markers and adipokines and their posible correlations in patients with PCa. Materials and methods: we studied 50 PCa patients diagnosed by transrectal ultrasound and biopsia (Gleason < 6) and 50 controls with normal digital rectal examination, and Prostate Specific Antigen (PSAt) < 2,50 ng/ml (50-65 years old). Total testosterone (To), free To (FTo), bioavailable To (BioTo), SHBG, HDL-chol and triglycerides (TG) were measured in all of them. TG/HDL-chol index was calculated as a secondary marker of IR, as well as free androgen index (FAI) and body mass index (BMI). Aditionally, adiponectine, insulin, estradiol and PCR-hs were measured in a subgroup of 20 PCa patients and 20 controls. Statistical analysis was performed through test t for independent samples and Spearman correlation. Results: data are expressed  as mean ± standard error TABLE 1 PCa (n=50) Controls (n=50) BMI (kg/m2) 28±0.8 27±0.8 TG/HDL-chol 4.3±0.44 c 3.3±0.40 PSAt (ng/ml) 6.20±0.84 d 0.22±0.01 To (ng/ml) 4.8±1.7 4.2±1.7 FTo (ng/ml) 89.8±30.9ª 68.8±28.5 BioTo (ng/ml) 2.06±0.71ª 1.58±0.66 SHBG (nM) 41.6±13.5 47.9±15.8 FAI 42.2±12.7ª 31.2±11.8  a p=0.06; b p<0.01 ; c p<0.05; d p<0.0001   TABLE 2 PCa (n=25) Controls (n=25) Insulin (uUI/ml) 10.5±1.2 10.5±1.4 PCR-hs (mg/l) 1.8±0.6 1.0±0.2 Adiponectine(ug/ml) 12.0±1.8a 20.1±3.1 Estradiol (pg/ml) 36b 26 a p=0.03  b p=0.01   There was a positive correlation between PSA and FAI (r=0.38, p=0.001), estradiol (r=0.31, p=0.008), BioTo (r=0.32, p=0.001) and PCR-hs (r= 0.31, p=0.03) and a tendency with TG/HDL-chol (r= 0.19, p=0.08). PSA also showed negative correlations with SHBG (r=-0.20,p=0.015) and adiponectine (r=-0.35, p=0.05). Conclusions: PCa patients showed greater androgenicity, with lower SHBG levels which in turn results in higher FTo, BioTo and FAI. SHBG diminution and TG/HDL-chol increase should evidence a greater IR degree. We observed a significant adiponectine diminution, independently of BMI. Higher degree of inflammation and androgenicity should be associated with  PSA increment.