INVESTIGADORES
BERG Gabriela Alicia
artículos
Título:
HDL-associated enzymes and proteins in hemodialysis patients
Autor/es:
CACCIAGIÚ L; GONZÁLEZ AI; GOMEZ ROSSO L; MEROÑO T; DE MARZIANI G; ELBERT A; BERG G; BRITES F; SCHREIER L
Revista:
CLINICAL BIOCHEMISTRY
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 2012 p. 243 - 248
ISSN:
0009-9120
Resumen:
OBJECTIVES:
To evaluate HDL-associated proteins and enzymes and their relation with lipoprotein profile and inflammatory markers in chronic renal patients on hemodialysis.
DESIGN AND METHODS:
We studied 53 patients under hemodialysis
and 32 healthy subjects as controls. We compared plasma lipids,
Apoprotein-AI and hs-CRP, as a marker of chronic inflammation. We
evaluated proteins and enzymes
associated to HDL, involved in several points of lipoprotein
metabolism: CETP, paraoxonase and LpPLA2 activities. Hepatic lipase was
measured in postheparin plasma.
RESULTS:
Patients
showed higher triglycerides and lower LDL-, HDL- and total-cholesterol
than controls (p<0.05). Also, in comparison with controls,
Apoprotein-AI, paraoxonase and hepatic lipase were lower, while CETP was
higher (p<0.03). LpPLA2 did not show changes between groups.
CONCLUSION:
Beyond
plasma lipid-lipoprotein profile, other factors could contribute to
induce a pro-oxidative and pro-inflammatory status. The protective role
of HDL does not only depend on its concentration, but also on its
functionality.