Association between testosterone levels and the metabolic syndrome in adult men

GROSMAN H; ROSALES M; FABRE B; NOLAZCO C; MAZZA O; BERG G; MESCH V

AGING MALE

INFORMA HEALTHCARE

Lugar: London; Año: 2014 vol. 17 p. 161 - 165

1368-5538

Objective: To evaluate the relationship between testosterone levels and the metabolicsyndrome (MS) in men older than 45 years.Methods: Six hundred and sixty men (45?70 years) selected from 2906 participants of apopulation screening for prostate cancer were included in this study. Testosterone andthe components of MS were assessed in all men. MS was diagnosed according to NCEP-ATP IIIcriteria. Triglycerides (TG)/HDL-cholesterol (chol) index was calculated.Results: The presence of MS was inversely associated with testosterone (2, p50.001),independently of age (OR 0.802, CI 95%: 0.724?0.887, p50.0001). Hypertension was the mostfrequent abnormality observed followed by elevated TG and waist circumference (WC).Testosterone correlated positively with HDL-chol (r: 0.14, p50.0001) and negatively with bodymass index (BMI)(r: 0.29, p50.0001), WC (r: 0.26, p50.0001), TG (r: 0.20, p50.0001),TG/HDL-chol (r: 0.20, p50.0001), glucose (r: 0.11, p¼0.005) and MS score (r: 0.23,p50.0001).Conclusions: Our results show that in men older than 45 years, as long as testosteronelevels decline, the prevalence of MS increases, independently of age. The correlations foundbetween testosterone and four of the five components of MS, as well as with BMI and TG/HDLcholratio, a surrogate marker of insulin resistance, suggest considering male hypogonadismas a determinant of developmental abnormalities typical of MS.