Adiponectin and waist circumference as predictors of insulin-resistance in women

BONNEAU, GRACIELA; PEDROZO WALTER; BERG, GABRIELA

Diabetes and Metabolic Syndrome: Clinical Research and Review

Elsevier

Año: 2014 vol. 8 p. 3 - 7

1871-4021

Background and aims: The initial disturbance of insulin resistance seems to focus on adipose tissue is adynamic organ involved in many physiological and metabolic processes. Expresses and secretes a varietyof active peptides, adipocytokines. To evaluate the prevalence of insulin-resistance in an healthy urbanmiddle age population and to explore the role of adiponectin, inflammatory biomarkers (hs-CRP) andtraditional cardiovascular risk factors as predictors of the insulin-resistance state.Materials and methods: We studied of 176 participants (117 women and 59 men, 25?74 years),individuals with diabetes, hypothyroidism or hyperthyroidism, infectious disease, renal, or hepaticneoplasms and pregnant women were excluded. We evaluated glucose, insulin, adiponectin and hs-CRP.Results: We found that 17.2% of individuals presented insulin-resistance. Correlation was foundbetween waist circumference, body mass index, blood pressure and HOMA index (p < 0.01). Adiponectinwas associated with the insulin-resistance (p < 0.001) but not hs-CRP. Adiponectin (b = 0.385, p = 0.004)and waist circumference (b = 0.116, p = 0.02) were predictors of IR only in women, meanwhile none ofthe analyzed biomarkers predicted insulin-resistance in men. Besides, postmenopausal womenpresented higher adiponectin levels than premenopausal 7.63 (4.46?9.58) vs 5.50 (3.83?7.40) mg/ml,p = 0.01.Conclusions: Adiponectin and waist circumference are important predictors of insulin-resistance even inhealthy non-diabetic women, they may open a new opportunity to improve current risk estimation.