SHP-1 in Cell-Cycle Regulation

PILAR LÓPEZ-RUIZ; JAVIER RODRIGUEZ-UBREVA; ARIEL E. CARIAGA-MARTINEZ; M. ALICIA CORTÉS; BEGOÑA COLÁS

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY

BENTHAM SCIENCE PUBL LTD

Lugar: Oak Park; Año: 2011 vol. 11 p. 89 - 98

1871-5206

Factor de impacto: 2,862/ Journal Ranking: Q2. Abstract: The reversible phosphorylation of tyrosine residues in proteins, which is governed by the balanced action of protein tyrosinekinases (PTKs) and protein tyrosine phosphatases (PTPs), is a key element of the signaling pathways that are involved in the control ofcell proliferation. Deregulation of either of these key regulators leads to abnormal cell signaling, which is largely associated with humanpathologies including cancer. This review focuses on recent studies on the role of the protein tyrosine phosphatase SHP-1 on cell-cycleregulation and its possible roles in tumour onset and progression. SHP-1 is a PTP with two SH2 domains that is expressed in haematopoieticcells and, moderately, in many other cell types, especially malignant epithelial cells. SHP-1 regulates cell proliferation, whetherit is by controlling mitogenic pathways activated by receptors with tyrosine kinase activity, or by regulating components of the cell-cyclemachinery such as CDK2, p27 and cyclin D1. Since several inhibitors targeting SHP-1 have demonstrated their value in cancer treatment,this phosphatase has been proposed as a therapeutic target for this pathology.