Nondysphoric depression in Parkinsons disease and frontotemporal dementia.

PABLO RICHLY; FACUNDO MANES; EZEQUIEL GLEICHGERRCHT; ANABEL CHADE; GONZALO GOMEZ AREVALO; OSCAR GERSHANIK; MARÍA ROCA; S. PARADISO

Buenos Aires

Congreso; International Congress of Parkinson's Disease and Movement Disorders; 2010

The International Parkinson and Movement Disorder Society (MDS)

Objective: The porpouse of this study was to compare the prevalence of Nondysphoric Depression (NDD) in Parkinson Disease (PD) and Frontotemporal Dementia (FTD). Background: NDD is one of the subsyndromal conditions characterized by depressive symptoms not endorsing sadness or anhedonia (i.e, dysphoria). Several empirical studies have found that this condition may be a long-term risk factor for cognitive decline and mortality. There are previous studies in neuropsychiatric patients, with a NDD prevalence of 6.6%, associated with right hemisphere stoke. Methods: Patients meeting criteria of early stage Parkinson Disease (Hoehn & Yahr I and II) and Frontotemporal Dementia were prospectively studied with the Beck Depressive Inventory (BDI-II). Patients meet criteria for Depression with a total score of 10 or more. Patients met NDD criteria when depressed mood or lack of pleasure were absent (items 1,4,12,21), and at least one psychological symptom (items 5, 9,14) and two vegetative symptoms (items 13,15,16,18,19,20) were present. Results: The groups were successfully matched for age (t = 1.00, df = 72, p = .32) and gender (Chi2 = 0.22, df = 1, p = .64). PD patients (n=37) were 60 years of age on average (SD 10,3). There were 54% depressive subjects and 2.7% subjects meeting NDD criteria in this group. FTD patients (n=37) presented an average age of 69.9 years (SD 8,2). There were 48.6% depressive subjects and 18.9% subjects meeting NDD criteria in this group. 57% of NDD patients also met depression criteria for depression. The average age of NDD patients was 70.4 years versus 69.8 in non-NDD subjects. The prevalence of NDD and depression in the behavioral variant FTD (bvFTD n=24) was 12.5% and 45.8%, while in the temporal variant FTD (tvFTD, n=13), it was 30.7% and 53%, respectively. Conclusions: Approximately half of PD and FTD patients met depression criteria. Our findings showed that nondysphoric depression is less common in patients with PD compared with FTD patients.