MATERNAL PRIMING IN INFANCY WITH WHOLE CELL BUT NOT ACELLULAR PERTUSSIS VACCINE LEADS TO A MORE DURABLE AND ROBUST PROTECTIVE RESPONSE IN NEONATAL MICE

MARTIN AISPURO, PABLO; BOTTERO DANIELA; DANIELA HOZBOR

Mar del Plata

Congreso; Reunión Anual de Sociedades de Biociencias SAIC | SAI | SAFIS 16 al 19 de Noviembre 2022 Mar del Plata. Buenos Aires Argentina; 2022

The introduction of massive vaccination in the 50s dramatically reduced the mortality associated with pertussis. In the last years, however the incidence rates have increased. Since in many countries the use of cellular vaccines (wP) to cover the primary doses was changed to acellular vaccine (aP), the controversy regarding the convenience of using one or another vaccine arose. To generate evidence in this regard and to determine immunological differences between aP and wP priming in neonates born to mothers vaccinated with aP during pregnancy (aPpreg), we used the intranasal challenge mouse model. We vaccinated female mice with wP-wP-aPpreg or aP-aP-aPpreg and measured offspring protection against B. pertussis challenge and specific-antibody levels with or without revaccination. Both immunization schemes protected the offspring against pertussis as evidenced by a reduction (5-6 logs,p