INVESTIGADORES
DEL MEDICO ZAJAC Maria Paula
artículos
Título:
Evaluation of modified vaccinia virus Ankara expressing VP2 protein of infectious bursal disease virus as an immunogen in chickens.
Autor/es:
ZANETTI, FLAVIA; DEL MEDICO ZAJAC, M. PAULA; TABOGA, OSCAR; CALAMANTE, GABRIELA
Revista:
JOURNAL OF VETERINARY SCIENCE
Editorial:
KOREAN SOC VETERINARY SCIENCE
Referencias:
Año: 2012 vol. 13 p. 199 - 201
ISSN:
1229-845X
Resumen:
A recombinant modified vaccinia Ankara (MVA) virus expressing mature viral protein 2 (VP2) of the infectious bursal disease virus (IBDV) was constructed to develop MVA-based vaccines for poultry. We demonstrated that this recombinant virus was able to induce a specific immune response by observing the production of anti-IBDV-seroneutralizing antibodies in specific pathogen-free chickens. Besides, as the epitopes of VP2 responsible to induce IBDV-neutralizing antibodies are discontinuous, our results suggest that VP2 protein expressed from MVA-VP2 maintained the correct conformational structure. To our knowledge, this is the first report on the usefulness of MVA-based vectors for developing recombinant vaccines for poultry.
