Increasing Radiosensitivity with histamine in 1205 Lu human melanoma cells.

NICOUD, MELISA B; MARTINEL LAMAS, D.J.; MASSARI, NOELIA A; BLANCO H; RIVERA, ES; MEDINA, V.A.

Málaga

Conferencia; European Histamine Research Society 44th Annual Meeting; 2015

EUROPEAN HISTAMINE RESEARCH SOCIETY

Melanoma is a highly metastatic cancer, which is markedly resistant to conventional therapy and its global incidence continues to increase. It was previously reported the expression of histamine receptors in melanoma cell lines and a role for histamine in melanoma cell growth. In addition, the radioprotective potential of histamine on healthy tissue has been previously demonstrated1. The use of drugs that preferentially either increase the tumor damage (radiosensitizers) or reduce the biological effects of ionizing radiation on normal tissue (radioprotectors), could improve therapeutic index of radiotherapy. The aim of this work was investigate the combinatorial effect of histamine and gamma radiation in vitro and in vivo on the radiobiological response of 1205Lu human melanoma cells. Histamine modified the radiobiological parameters of 1205Lu cells, increasing the radiosensitivity (SF2Gy 0.14±0.03 vs. 0.34±0.02 in untreated cells; α 1.06±0.01 vs. 0.42±0.07 in untreated cells, P