CLOZAPINE, A NEW THERAPEUTIC APPROACH FOR BREAST CANCER?

MELISA B NICOUD; MARTINEL LAMAS, D.J.; STERLE, HELENA A.; URIBURU, JUAN L.; CREMASCHI, GRACIELA A.; MEDINA, VANINA A

Mar del -Plata

Congreso; LXI REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA; 2016

Sociedad Argentina de Investigación Clínica

Previous data provide evidence supporting the anticancereffects of antipsychotics that could partially explain the lowerincidence of cancer in patients with schizophrenia comparedwith the general population. We have previously demonstratedthat clozapine inhibited proliferation of human breast cancer andmelanoma cells. The aim of this work was to investigate the invitro and in vivo antitumor activity of clozapine in 4T1 triple negativebreast cancer (TNBC) model. For that purpose, the effect ofclozapine on processes associated with cell death and survival,metabolism of ROS and DNA damage was studied in murine 4T1breast cancer cells. Clozapine effects on tumor progression wasfurther investigated in syngeneic mice, inoculated orthotopicallywith 4T1 murine TNBC cells. Results indicate that clozapine inhibitedclonogenic proliferation and produced a 2-fold decreasein BrdU incorporation of 4T1 cells (P