Methodological approaches to invastigate the effects of histamine receptor targeting compunds in preclinical models of breast cancer

MARTINEL LAMAS, DJ ; NICOUD, M.B.; STERLE, HA; MEDINA, VA

Histamine Receptors as drug targets

Human Press

Año: 2017; p. 1 - 517

Histamine [2-(4-imidazolyl) ethylamine] is a biogenic amine that is synthesized from the amino acid l-histidine through the catalytic activity of histidine decarboxylase (HDC, EC 4.1.1.22) and catabolized by two enzymes, namely diamine oxidase (DAO, EC 1.4.3.6) and histamine N-methyltransferase (HNMT, EC 2.1.1.8)The history of histamine and antihistamines reflects numerous pioneering moments in the development of pharmacology over the last 100 years, achieved by research groups led by outstanding scientists, including six Nobel Prize winners: Paul Ehrlich, Charles Richet, Adolf Windaus, Sir Henry Dale, Daniel Bovet, and Sir James Black. Histamine was chemically synthesized by Adolf Windaus and Karl Vogt in 1950, and the investigation of its pharmacological actions started in the early twentieth century by Sir Henry H. Dale in the Wellcome Research Laboratories in south-east London One of the first described actions of histamine was its ability to mimic the anaphylactic reaction. A few years earlier, Paul Portier and Charles R. Richet had coined the term?anaphylaxis? and Clemens von Pirquet and Bela Schick the term ?allergy? to describe the hypersensitivity reactions. However, it was not until the early 1950s that James Riley and Geoffrey West associated histamine with the mast cell which had been discovered more than 70 years earlier by Paul Ehrlich and was linked to anaphylactic reactions in 1941