Short-Term In Vivo Response to Anodized Magnesium Alloy as a Biodegradable Material for Bone Fracture Fixation Devices

MERLO, JULIETA LETICIA; KATUNAR, MARÍA ROSA; TANO DE LA HOZ, FLORENCIA; CARRIZO, SABRINA; SALEMME, ALONSO; OTAZ, MARÍA ALEJANDRA; BALLARRE, JOSEFINA; CERÉ, SILVIA

ACS Applied Bio Materials

ACS Applied Bio Materials

Lugar: Washington DC; Año: 2021 vol. 4 p. 7123 - 7133

2576-6422

Biodegradable materials based on magnesium alloys have a huge potential for bone fracture fixation devices due to their adequate mechanical properties and biocompatibility. However, theirfast degradation and the consequent liberation of hydrogen gas at the initial stages of implantation is the major limitation for their use. In this study, the AZ91D magnesium alloy was surface treated by an environment-friendly, nontoxic, and low-cost anodizing process and the early in vivo response was studied in a rat transcortical model. Adequate maturation of woven bone around implants detected at day 7 post implantation to lamellar bone was observed from day 15. Lamellar bone after 15 and 30 days of implantation presented similar volume, mineralization pattern, mineral to protein content, and estimated bone maturity between anodized AZ91D and polylactic acid (control) implants. Histology observation showed neither release of hydrogen bubbles in the region closed to the anodized AZ91D implant nor systemic effects on liver, kidney, and spleen. Thus, anodizing of AZ91D in the conditions stated here induced an adequate short-term in vivo response, which postulates their use as potential biodegradable fracture fixation devices for bone healing.