POTENTIAL NEUROPROTECTIVE EFFECT OF DDOX IN PARKINSON'S DISEASE MODELS: A NOVEL NON-ANTIBIOTIC DOXYCYCLINE DERIVATIVE WITH ALPHA-SYNUCLEIN ANTI-AGGREGATING PROPERTIES

TERÁN, MM; TOMAS GRAU, RH; SOLIZ SANTANDER, SE; LUNA MERCADO, A; ÁVILA, C; RAISMAN VOZARI, R; FIGADÈRE, B; PLOPER, D; CHEHÍN, R

San Luis

Congreso; XXXVIII Annual Meeting of the SAN; 2024

Parkinson´s disease (PD) is a chronic neurodegenerative disorder characterized by the loss of dopaminergic neurons due to misfoldingand aggregation of a-synuclein (aS) protein. Although Doxycycline (DOX) showed potential to interfere with aS aggregation, its antibiotic activity confers alimitation for long-term treatments. Thus, we synthesized and tested a reduced form of DOX (DDOX) with weaker antibiotic activity but improvedneuroprotective and anti-aggregant qualities.