PERSONAL DE APOYO
MICHINSKI SebastiÁn Diego
artículos
Título:
Minimally invasive electrochemotherapy procedure for treating nasal duct tumors in dogs using a single needle electrode
Autor/es:
MAGLIETTI, FELIPE; TELLADO, MATÍAS; OLAIZ, NAHUEL; MICHINSKI, SEBASTIAN; MARSHALL, GUILLERMO
Revista:
Radiology and Oncology
Editorial:
Association of Radiology and Oncology
Referencias:
Lugar: Ljubljana; Año: 2017 vol. 0
Resumen:
Background. Nasal cavity tumors are usually diagnosed late, when they already have infiltrated adjacent tissuesthus requiring very aggressive treatments with serious side effects. Here we use electrochemotherapy (ECT), a welldemonstrated treatment modality for superficial tumors.Materials and methods. In the case of deep-seated tumors, the main limitation of ECT is reaching the tumor withan appropriate electric field. To overcome this limitation we introduce the single needle electrode (SiNE), a minimallyinvasive device that can deliver an appropriate electric field with a simple procedure. Twenty-one canine patientswith spontaneous tumors were selected, eleven were treated using the SiNE with ECT, and ten with surgery plus adjuvantchemotherapy as a control group.Results. In the SiNE group, 27% achieved a complete response, 64% had a partial response, and 9% had a stabledisease. This means that 91% of objective responses were obtained. The mean overall survival was 16.86 months (4?32months, median 16.5 months), with a survival rate significantly higher (p = 0.0008) when compared with control group.The only side effect observed was the inflammation of the treated nasal passage, which was controlled with corticosteroidtherapy for one week. One year after the treatment, 60% of the canine of the SiNE group vs. 10% of the controlgroup remained alive, and after the 32 months follow-up, the survival rate were 30% and 0%, respectively.Conclusions. ECT with the SiNE can be safely used in canine to treat nasal tumors with encouraging results.