PERSONAL DE APOYO
LIVORE Veronica Ines
congresos y reuniones científicas
Título:
Effect of Insulin growth factor 1 binding protein 2 (IGF2BP1) knock down on the expression of multidrug resistance proteins in HepG2 cells.
Autor/es:
BUCCI MUÑOZ MARIA; SEMENIUK MARIANA; LIVORE VERONICA INES ; BANCHIO, CLAUDIA
Lugar:
ROSARIO
Reunión:
Congreso; SAFIS; 2019
Resumen:
Multidrug resistance associated protein 3 (MRP3/ABCC3) and Breast cancer resistance protein (BCRP/ABCG2) are export pumps that extrude endo- and xenobiotics out of the cells, such as chemotherapeutic drugs. MRP3 and BCRP overexpression leads to chemoresistance in tumoral cells. IGF2BP1 is an oncoprotein highly expressed in tumoral cells, which modulates protein expression by binding and stabilizing mRNAs. The aim of this study is to evaluate if IGF2BP1 regulates MRP3 and BCRP expression in HepG2 cells.
