Uniparental origins of the admixed Argentine Patagonia

TAMBURRINI, CAMILA; SAINT PIERRE, MICHELLE; BRAVI, CLAUDIO MARCELO; BAILLIET, GRACIELA; JURADO MEDINA, LAURA; VELÁZQUEZ, IRINA FLORENCIA; REAL, LUCIANO ESTEBAN; HOLLEY, ALFREDO; TEDESCHI, CLAUDIA MARCELA; BASSO, NÉSTOR GUILLERMO; PAROLIN, MARÍA LAURA

AMERICAN JOURNAL OF HUMAN BIOLOGY

WILEY-LISS, DIV JOHN WILEY & SONS INC

Lugar: New York; Año: 2021

1042-0533

Objectives: We aimed to contribute to the understanding of the ancient geographic origins of the uniparentally inherited markers in modern admixedArgentinian populations from central Patagonia with new information providedfor the city of Trelew. We attempted to highlight the importance of combiningdifferent genetic markers when studying population history.Methods: The mtDNA control region sequence was typified in 89 individualsand 12 Y-STR and 15 Y-SNP loci were analyzed in 66 males. With these data,analysis of molecular variance and Network analyses were carried out. Weexhaustively compared the modern data with ancient mtDNA information.Finally, we tested the differences in continental origins estimated by uniparentaland previously published biparental markers.Results: Native American mtDNAs (53.9%) increased when maternal ancestorswere born in the northern (81.8%) and southern (58.5%) regions of Argentina orin Chile (77.8%). Population substructure was only observed for Y-chromosomehaplotypes. Some mtDNA haplogroups have been present in the area for at leastca. 2762?2430 and ca. 500 (D1g and D1g4 haplogroups) and ca. 6736 andca. 6620 (C1b and C1c haplogroups) years, respectively. In contrast, haplogroupsB2i2 and C1b13, frequent in modern Patagonia populations, had not been foundin previous ancient DNA studies of the region.Conclusions: The results suggest that Native American ancestry is well preservedin the region. Trelew samples had characteristic native mtDNA haplogroups previouslydescribed in Chilean and Argentine Patagonian populations, but notobserved in ancient samples until now. These findings support the idea that theselineages have a recent regional origin. Finally, the estimated proportions of continentalancestry depend on the genetic marker analyzed