Evidence for Effects on Thermoregulation after Acute Oral Exposure to Type I and Type II Pyrethroids in Infant Rats.

ULISES BARDULLAS; CARLA SOLANGE SOSA-HOLT; ALEJANDRO MARTÍN PATO; SERGIO IVÁN NEMIROVSKY; MARCELO JAVIER WOLANSKY

NEUROTOXICOLOGY AND TERATOLOGY.

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2015 vol. 52

0892-0362

Most pyrethroid (PYR) insecticides may be classified either as type-I compounds, which produce whole body tremors and hyperthermia, or type-II compounds, which produce salivation, choreoathetosis, and hypothermia (i.e., producing T and CS neurobehavioral syndromes, respectively). This classification is based on clinical obser- vations in adult rats and mice after intracerebroventricular or intravascular administration of highly effective acute (bolus) doses. PYR neurotoxicity in infant animals is not characterized as much as in adult animals. End- points informing on vital determinants of mammal´s maturation, such as body temperature may help recognizing age-related differences in susceptibility to PYRs. In this work, body temperature (Tb ) was monitored at 30-min intervals after acute oral exposure to T-syndrome PYR bifenthrin (BIF), CS-syndrome PYR cypermethrin (CYPM), and a BIF?CYPM mixture in weanling rats by using a subcutaneous temperature monitoring system. In both single-compound assays, a time- and dose-related decline of Tb was the most evident impact on thermo- regulation observed starting at ~2?3 h after dosing. Moreover, 15?18 mg/kg BIF induced a mild increase in Tb be- fore the hypothermic action was apparent. The lowest effective dose for temperature perturbation was 15 mg/kg for BIF and 10 mg/kg for CYPM, and moderate neurobehavioral alterations were evident at 12 and 10 mg/kg, re- spectively. When low effective doses of BIF and CYPM were co-administered mild behavioral effects and a tran- sient increase in Tb (p = 0.02) were observed at 1?2 h, and no Tb decline was apparent afterwards compared to control animals. Noteworthy, the hypothermic action of BIF in infant rats was quite different from the hyperther- mia consistently reported in studies using mature animals. Our results suggest that body temperature monitoring may be useful as a complementary assessment to reveal qualitative age-specific pesticide effects in rats.