"One-Pot Palladium-Catalyzed Phosphination of Aryl Iodides with Ph2PSnR3"

SANDRA E. MARTÍN, MARIANA BONATERRA AND ROBERTO A. ROSSI

JOURNAL OF ORGANOMETALLIC CHEMISTRY

ELSEVIER SCIENCE SA

Año: 2002 vol. 664 p. 223 - 227

0022-328X

We found a very efficient one-pot phosphination reaction starting with Ph3P, which by reaction with Na metal in liquid ammonia gives Ph2P ions that reacted with R3SnCl to afford (trialkylstannyl)diphenylphosphine. The palladium-catalyzed coupling reaction of these stannanes with aryl iodides yield functionalized phosphines in high yield (69/97%). The use of Ph3P as starting reagent, the endurance of the reaction to a wide variety of functional groups and the easiness of a one-pot reaction make this method a useful and versatile approach to tertiary phosphine oxides.