Beneficial effect of zinc supplementation on cardiometabolic alterations induced by high fat and fructose diet in Wistar rats

PÁEZ, DIAMELA; MEDINA, AGUSTINA; POLERO, FRANCO; GAETANI, JUAN MANUEL; NOCETI, GABRIELA; MORIONDO, MARISA; OLANO, CAROLINA; ZAGO, VALERIA; ELESGARAY, ROSANA; CANIFFI, CAROLINA; ARRANZ, CRISTINA T; TOMAT, ANALÍA LORENA

Mar del Plata

Congreso; Reunión Anual de Sociedades de Biociencias; 2022

Sociedad Argentina de Investigación Clínica

Introduction:We demonstrated that zinc deficiency during fetal and postnatal life induced cardiometabolic alterations in adult male rats. Zinc could play an import role attenuating these alterations due to its antioxidant properties and the multiple functions in glucose metabolism. Objective:To evaluate the effect of postweaning zinc supplementation on intermediate metabolism, retroperitoneal adipose tissue (RAPT), plasma lipid peroxidation (TBARS) and systolic blood pressure (SBP) in adult male Wistar rats fed a high fat and fructose diet during growth. Methods:Female rats were fed a control diet (C,30ppm) during the pregnancy and lactation periods. At day 21 male offspring were weaned and randomly fed a control diet (CC,30 ppm), high fat-control zinc diet and fructose 10% in drinking water (CHF, fat 60 % kcal, zinc: 30 ppm) or high fat-supplemented zinc diet and fructose 10% in drinking water (ZHF,190 ppm). At day 81 serum metabolic profiles, plasmatic TBARS, SBP and RPAT morphology were evaluated. Values are mean±SEM. Two-way ANOVA, Bonferroni post-test:***p