Amyloid-β induces endothelial endoplasmic reticulum stress in association with blood-brain barrier disruption in experimental models of Alzheimer?s disease.

CARLOS POMILIO; JESSICA PRESA; NICOLÁS GABRIEL GONZÁLEZ PÉREZ; ÁNGELES VINUESA; MELISA BENTIVEGNA; AMAL GREGOSA; KIM KS; GALVÁN VERONICA; JUAN BEAUQUIS; FLAVIA SARAVIA

Congreso; Reunión anual de la Sociedad Argentina de Investigaciones Clínicas; 2020

Alzheimer?s disease (AD) is the leading cause of dementia. Among other histopathological hallmarks, it is characterized by the abnormal accumulation of Amyloid-β (Aβ) peptides. Vascular alterations and blood-brain barrier disruption are also evidenced in AD patients, in close association with perivascular amyloid deposits, which are composed mainly of Aβ 1-40. In this study we characterized the progression of vascular alterations in the hippocampus of PDAPP-J20 mice, a validated transgenic model for AD. We found a significant increment in morphological alterations in hippocampal vessels from AD mice compared to age-matched controls (p