Early exposure to a high fat diet promotes cognitive impairment, neuroinflammation and decreased hippocampal plasticity. Possible implication of microglia- derived exosome- like extracellular vesicles.

ÁNGELES VINUESA; BENTIVEGNA MELISA; CALFA, GASTÓN; FABIA FILIPELLO; CARLOS POMILIO; BONAVENTURA, MARÍA MARTA; LUX-LANTOS, VICTORIA; AMAL GREGOSA; JESSICA PRESA; MICHELA MATTEOLI; JUAN BEAUQUIS; FLAVIA SARAVIA

Congreso; Reunión anual de la Sociedad Argentina de Investigaciones Clínicas; 2018

Western dietary habits including high fat-industrialized foods are in¬creasingly represented in juvenile populations and constitute one of the factors that affect brain health, potentially leading to long lasting effects. Adolescence, characterized by brain maturation and behav¬ioral changes, is particularly vulnerable to the environment. Hence, our aim was to study the impact of an early exposure to a high fat diet (HFD) on mouse hippocampal plasticity and cognition. To that end, C57BL/6J male mice were exposed to HFD for 6 weeks since weaning. Glycemia and seric proinflammatory IL1β were higher in HFD mice (p