Microglial alterations before plaque deposition in PDAPP-J20 mice, model of Alzheimer?s Disease.

PAVIA PATRICIO; VINUESA ANGELES; POMILIO CARLOS; BEAUQUIS JUAN; SARAVIA FLAVIA

Huerta Grande

Congreso; Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias; 2014

Sociedad Argentina de Investigación en Neurociencias

Alzheimer´s disease (AD) is a progressive neurodegenerative disease without effective therapy and the principal cause of dementia. Brain amyloid deposits are classical histopathological hallmarks that generate an inflammatory reaction affecting neuronal and glial function. The identification of early cell changes and of brain areas involved could help to design new successful treatments. Hence, we studied early alterations of hippocampal microglia and their progression during the pathology in PDAPP-J20 transgenic mice, carrying human APP gene with Swe and Ind mutations, at 3, 9 and 15 months (m) of age. Age-matched non transgenic mice were used as controls. At 3 m, before plaque formation, Iba1+ cells from transgenic mice already exhibited signs of activation and larger soma size in the hilus (42.16 ± 5.95 µm2 vs 34.54 ± 2.01 µm2, p