Consumption of a high fat diet in early stages of life induces cognitive impairment and hippocampal changes in C57BL/6 mice

MELISA BENTIVEGNA; ÁNGELES VINUESA; CARLOS POMILIO; JESSICA PRESA; AMAL GREGOSA; FLAVIA SARAVIA; JUAN BEAUQUIS

Congreso; Congreso Anual de la Sociedad Argentina de Investigaciones Clínicas; 2017

Sociedad Argentina de Investigación en Neurociencias

Insulin resistance and obesity associated with the consumption of hyperlipidic diets are considered risk factors for the development of cognitive disorders and neurodegenerative diseases such as Alzheimer´s disease. Insulin resistance, inflammation and cognitive dysfunction are common manifestations in the context of both neurodegenerative and metabolic pathologies. Our objective is to study the effect of juvenile exposure to a moderately high fat diet (HFD), since weaning until 2 months of age, on cognitive performance and hippocampal glial and neuronal changes in C57BL/6 mice. HFD exposure induced an increase in blood glucose and peripheral inflammation shown by significantly augmented levels of seric IL1 (p