INVESTIGADORES
POMILIO Carlos Javier
congresos y reuniones científicas
Título:
Evidence of autophagy dysregulation on microglial cells in the context of Alzheimer?s disease using in vitro and in vivo models
Autor/es:
CARLOS POMILIO; AGUSTINA ALAIMO; ROXANA GOROJOD; ÁNGELES VINUESA; JESSICA PRESA; MELISA BENTIVEGNA; SOLEDAD PORTE ALCÓN; JUAN BEAUQUIS; JUAN BONIFACINO; MÓNICA KOTLER; FLAVIA SARAVIA
Lugar:
Buenos Aires
Reunión:
Jornada; Jornadas Interdisciplinarias de Química Biológica; 2017
Institución organizadora:
Departamento de Química Biológica (FCEyN-UBA)
Resumen:
Alzheimer´s disease (AD) is the principal cause of dementia in the elderly. A recognized hallmark of AD is the aggregation of Amyloid-β peptides (Aβ) into senile plaques, frequently surrounded by hypertrophied glial cells. We studied microglial alterations in the hippocampus of PDAPP mice, a well-established transgenic model of AD. Before detection of plaques in the brain, we found an early increase in the Iba1+ soma related area and activation score (p
