COMPARATIVE EFFICACY OF COMBINED TREATMENTS USING METRONOMIC CHEMOTHERAPY (MCT) PLUS REPOSITIONED DRUGS (RD) ON A MURINE TRIPLE NEGATIVE MAMMARY ADENOCARCINOMA

MARÍA JOSÉ RICO; LEANDRO E MAINETTI; MARÍA VIRGINIA BAGLIONI; MAURICIO MENACHO MÁRQUEZ; VIVIANA R. ROZADOS; O. GRACIELA SCHAROVSKY

Congreso; Reunión Anual de Sociedades de Biociencias; 2020

MCT consists of the chronic, equally spaced administration of drugsat low doses without extended rest periods. RD are compoundsoriginally formulated for other indications that showed antitumor potential.Previously, we inoculated the triple negative (TN) mammarytumor M-406 in syngeneic CBi mice and studied, separately, the effectof four combined MCT schemes administered in the drinkingwater: A) Cyclophosphamide (Cy)30 mg/kg/d + celecoxib 30 mg/kg/d, B) Cy 20 mg/kg/d + metformin (M) 400 mg/kg/d C) M 400 mg/kg/d + propranolol 7 mg/kg/d, D) Cy 25mg/kg/d + losartan 150 mg/kg/d. Our aim was to compare the results of MCT therapeutic effectfor all the drugs combinations, in order to identify the most effectivetreatment. The % of reduction of tumor volume respect to thecontrol group without treatment [median (range), A:77.9(50.9-89.9),B:82.3(59.9-93.4), C:61.4(31.9-70.8), D:94.9(80.5-99.8)] differedsignificantly among treatments (nonparametric ANOVA P