ENRICHMENT ANALYSIS ASSOCIATED TO VAV3 EXPRESSION IN MELANOMA

AYLÉN ÁVILA; MAURICIO MENACHO MÁRQUEZ; LUCIANO ANSELMINO

Congreso; Reunión Conjunta SAIC. SAI. AAFE. NANOMED-AR; 2021

Skin cutaneous melanoma (SKCM) is the most severe form of skincancer, originated from the malignant transformation and proliferation of melanocytes.According to the existing paradigm for the Rho GEFs (guanine nucleotide exchange factors), the Vav subfamily is commonly assumedto be involved in protumorigenic pathways in tumor cells. Interestingly, we have recently proposed an unexpected tumor suppressorrole for Vav3 in melanoma. In this tumor type, Vav proteins playimportant roles during development, tumor growth and metastasis.In this work, we explore molecular functions associated to Vav3 inmelanoma by bioinformatics. First, by survival analysis tools andusing human patient databases, we found that Vav3 expression correlated with patient survival (p1 and FDR