DRUG REPOSITIONING FOR CANCER TREATMENT: METRONOMIC THERAPY WITH CHLOROQUINE AND PROPRANOLOL

GEORGINA REYNOSO; MARÍA VIRGINIA BAGLIONI; MARÍA JOSÉ RICO; VIVIANA R. ROZADOS; O. GRACIELA SCHAROVSKY; MAURICIO MENACHO MÁRQUEZ

Mar del Plata

Congreso; LXI Reunión Anual de la Sociedad de Investigación Clínica; 2016

SAIC

Drug repositioning or repurposing in oncology refers to the use of drugs originally formulated to other indications that showed antitumor potential. In this work we made a screening of repurposing drugs that included metformin (diabetes treatment), propranolol (P; indicated to treat hypertension), doxycycline (antibiotic), chloroquine (C; malaria treatment or prevention), DHEA (sexual hormones precursor) and orlistat (obesity treatment). The antitumor potential of these drugs was evaluated in vitro in a murine triple negative breast cancer (TNBC) model (4T1 cells) through standard viability assays, either individually or in a combined manner. From the combinations tested, C+P resulted attractive as it showed a strong growth inhibition even combining low doses of both drugs (P