INVESTIGADORES
MENACHO MÁRQUEZ Mauricio Ariel
congresos y reuniones científicas
Título:
A functional link between the MRN complex and the Gcn2p kinase uncovered by the antitumour drug beta-lapachone
Autor/es:
JOSÉ RAMÓN MURGUÍA; MAURICIO ARIEL MENACHO; PÉREZ-VALLE, J; GADEA, J; ARIÑO, J
Lugar:
Lyon
Reunión:
Congreso; European Association of Cancer Research Annual Meeting; 2008
Institución organizadora:
EACR
Resumen:
Background: Beta-lapachone (b-lap) is an anticancer agent that selectively induces cell death in several human cancer cells. We previously reported that, in budding yeast, b-lap was cytotoxic, induced DNA damage and activated a G1/S Mre11-Tel1p checkpoint pathway preceding death. Our aim was to gain further insights into the mechanism of b-lap action and identify the molecular targets of b-lap action.
