A NOVEL IMPLICATION OF NEURONAL PROTEINS IN CANCER: CHARACTERIZING THE ROLE OF SYNUCLEIN PROTEINS IN MELANOMA

LUCÍA ZANOTTI; FLORENCIA MALIZIA; MENACHO MÁRQUEZ, MAURICIO

Congreso; Reunión Conjunta SAIC. SAI. AAFE. NANOMED-AR; 2021

Synucleins are small proteins expressed primarily in neural tissue and certain tumors. While alpha-synuclein (aS) was recently connected to melanoma development, gamma-synuclein (gS) was associated with a range of tumor types. Our goal was to explore the role aS and gS in melanoma. For that, we worked with mouse (B16F0, B16F10) and human (SKMEL28, A375) melanoma cells. By Western Blot (WB) and immunocytochemistry (ICC), we observed that both proteins were expressed in these cells.