INVESTIGADORES
MENACHO MÁRQUEZ Mauricio Ariel
artículos
Título:
Modern Strategies in Cancer Study: Drug Repositioning in Colorectal Cancer Treatment
Autor/es:
LUCIANO ANSELMINO; FLORENCIA MALIZIA; MAURICIO MENACHO MÁRQUEZ
Revista:
Novel Approaches in Cancer Study
Editorial:
Crimson Publisher
Referencias:
Lugar: NY; Año: 2019
ISSN:
2637-773X
Resumen:
Colorectal cancer is one of the most fatal cancers in the world because most of cases are diagnosedin advanced stages, when the development of resistance to chemotherapy is more frequent. To face thissituation, new drugs and drug combinations would be necessary. Drug discovery is a very costly process;although efforts in drug discovery have been amplified in recent decades the success rate of approvedFDA drugs continues being low. In response to this situation the repositioning of drugs proposes to delveinto the genetic, epigenetic and metabolic differences to discover new targets and redirect drugs alreadyapproved to the treatment of other diseases and conditions. In this minireview we discuss the mainavenues in which repositioning can occur and we cite some examples of rep
