INVESTIGADORES
MENACHO MÁRQUEZ Mauricio Ariel
artículos
Título:
Vav proteins are key regulators of Card9 signaling for innate antifungal immunity
Autor/es:
SUSANNE ROTH; HANNA BERGMANN; MARTIN JAEGER; ASSA YEROSLAVIZ; KONSTANTIN NEUMANN; PAUL-ALBERT KOENIG; CLARISSA PRAZERES DA COSTA; VINOD KUMAR; MELISSA JOHNSON; MAURICIO MENACHO MÁRQUEZ; BIANCA HABERMANN; VICTOR L TYBULEWICZ; MIHAI NETEA; XOSÉ R. BUSTELO; JÜRGEN RULAND
Revista:
Cell Reports
Editorial:
Cell
Referencias:
Año: 2016
ISSN:
2211-1247
Resumen:
Fungal infections are major causes of morbidity and mortality, especially in immunocompromised individuals. The innate immune system senses fungal pathogens through Syk-coupled C-type lectin receptors (CLRs), which signal through the conserved immune adapter Card9. Although Card9 is essential for antifungal defense, the mechanisms that couple CLR-proximal events to Card9 control are not well defined. Here, we identified Vav proteins as key activators of the Card9 pathway.
