DNA damage signalling in eukaryotes: learning from budding yeast

MAURICIO ARIEL MENACHO; JOSÉ RAMÓN MURGUÍA

Revista de Oncología

ELSEVIER

Año: 2003 vol. 5 p. 139 - 147

1575-3018

Cell cycle checkpoints ensure the order of cell cycle events to preserve genome integrity. Among those, the DNA damage checkpoints prevent chromosome segregation when DNA is damaged. Defects in DNA damage signalling impair the cell ability to repair DNA lesions leading to cancer predisposition in humans. Advances in budding yeast have underlined the regulatory networks for these pathways, which are conserved throughout evolution, allowing a better understanding of how these controls sense and transduce the DNA damage signal. However, the molecular basis of DNA damage recognition and the coordinated regulation of DNA repair networks by checkpoint controls still remain unclear