Infection by T. cruzi up-regulates the catabolic pathway of tryptophan in human placental villi

M. VARA MESLER 1 , G.M. MAZZUDULLI 1 , M. PIEGARI 1 , L. MEZZANO 1 , C. DÍAZLUJAN 1,2 , M.F. TRIQUELL 1,2 , R.E. FRETES 1,2 .

PLACENTA

W B SAUNDERS CO LTD

Lugar: Londres; Año: 2017 vol. 51

0143-4004

Tryptophan catabolic pathway participates in immunologic tolerance ofthe foeto-maternal relationship. Indoleamine 2,3-dioxygenase (IDO)which contributes to immune regulation by catalyzing the essential aminoacid tryptophan along the kynurenine (Kyn) pathway, is highly expressedin the placenta. In turn, Kyn is a natural ligand for Aryl hydrocarbon receptor(AhR). This system has been described to participate in the infectionof Chagas disease, but the interaction of placental tissue with Trypanosomacruzi (T. cruzi), the c