BECAS
ABATE Pedro Oscar
artículos
Título:
A Symmetrical Dirhenium(I) Complex with 4,4??-Azobis(2,2?-bipyridine) as a Bridging Ligand: Synthesis, Physicochemical Properties and Applications in Detection of Biologically Relevant Thiols and in Chemotherapy for Bone Cancer
Autor/es:
ABATE, PEDRO O.; SOTTILE, MARCO; LEÓN, IGNACIO E.; VERGARA, MÓNICA M.; KATZ, NÉSTOR E.
Revista:
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
Editorial:
SOC BRASILEIRA QUIMICA
Referencias:
Lugar: San Pablo; Año: 2020 vol. 31
ISSN:
0103-5053
Resumen:
A new dinuclear complex of formula [{Re(CO)3(py)}2(µ-4,4?-azobpy)](PF6)2, with py = pyridine and 4,4?-azobpy = 4,4?-azobis(2,2?-bipyridine), has been synthesized and characterized by spectroscopic and electrochemical techniques. The symmetrical nature of the dimetallic cation has been confirmed by nuclear magnetic resonance (NMR) measurements. When adding L-cysteine or L-glutathione, large and rapid changes in its UV-Vis absorption spectra were observed, which can be used for detecting both biologically relevant thiols. A promising activity for using this complex as a chemotherapeutic agent for bone cancer was also disclosed. Quantum mechanical calculations supported the experimental data.
