Novel poly(NIPA-co-AAc) functional hydrogels with potential application in oral drug controlled release

JULIO CÉSAR CUGGINO; CINTIA BELÉN CONTRERAS; ALVARO JIMENEZ-KAIRUZ; BELKYS ANGÉLICA MALETTO; CECILIA INÉS ALVAREZ IGARZABAL

Simposio; SLAP 2014: XIV Simposio Latinoamericano de Polímeros; 2014

The synthesis, characterization and properties of pH / thermo-sensitive hydrogels based on acrylic acid (AAc) and Nisopropylacrylamide (NIPA) using (+)-N,N′-diallyltartramide (DAT) as crosslinking agent and water as solvent, are presented in this work. Subsequently, the incorporation of ofloxacin (OFL) as model drug to evaluate the drug load capacity of hydrogels and the in vitro release from OFL-polymer conjugate are presented in order to define potential pharmaceutical applications. Interestingly, the incorporation of AAc diversified the properties of NIPA-based hydrogels allowing ionic interaction of these new materials with drugs of opposite charge and produced different release profiles at pH 1.2 and 6.8 simulated physiological media which give to these new materials potential applications as carrier in smart oral drug delivery formulations.