CLINICAL AND MOLECULAR STUDY OF A CASE OF SEVERE RADIO-SENSITIVITY

OCOLOTOBICHE, ELIANA EVELINA; CÓRDOBA, ELISA EUGENIA ; GÜERCI, ALBA MABEL

International Journal of Radiology & Radiation Therapy

MedCrave

Año: 2019

A case of a patient with a breast intraductal tumor is presented. The patient underwent surgical quadrantectomy and axillary lymph node dissection and subsequently received Anthracycline treatment and 3D radiotherapy following a standard fractionation protocol. This case was characterized by the development of grade III dermal toxicity, some associated genetic polymorphisms and DNA damage were analyzed. We concluded that radiotoxicity is a multifactorial phenotype that should be addressed in a broader context, considering not only intrinsic variables but also criteria such as breast size, body mass index and concomitant treatments, among others.