Oxidovanadium(IV) Complexes with Flavonoids. Anticancer activity and mechanisms of action in human colon adenocarcinoma model: role of activation of nfkb and apoptosis.

LEÓN IE; MUGLIA CI; PORRO V; TISCORNIA I; DI VIRGILIO A.L; BOLLATI-FOGOLIN M.; ETCHEVERRY S.B.

Simposio; 9th International BioMetals Symposium; 2014

The family of polyphenolic flavonoids presents anti-inflammatory and anti-tumor effects. In particular, Chrysin and Silibinin are interesting members of this family, with potent anti-proliferative and anti-metastatic effects against various malignant cell lines. Oxidovanadium(IV) complexes show interesting pharmacological activity mainly as insulin enhancers, osteogenic and anti-tumor agents. In this work we report the biological effects of two complexes of vanadyl(IV) with Chrysin and Silibinin on a human colon adenocarcinoma cell line (HT-29 ATCC HTB 38). VOsil caused an inhibitory effect on cell viability in the range of 75-100 μM while VOchrys only provoked this effect at 100 μM (p