INVESTIGADORES
MARTÍNEZ MEDINA Juan JosÉ
congresos y reuniones científicas
Título:
Antitumoral, Antihypertensive, Antimicrobial, and Antioxidant Effects of an Octanuclear Copper(II)-Telmisartan Complex with an Hydrophobic Nanometer Hole
Autor/es:
MARÍA S. ISLAS; JUAN J. MARTÍNEZ MEDINA; LIBERTAD L. LÓPEZ TÉVEZ; LUIS LEZAMA; MERCEDES GRIERA MERINO; LAURA CALLEROS; MARÍA A. CORTES; TEÓFILO ROJO; MANUEL RODRIGUEZ PUYOL; GUSTAVO A. ECHEVERRÍA; OSCAR E. PIRO; EVELINA G. FERRER; PATRICIA A.M. WILLIAMS
Lugar:
Chascomús, Buenos Aires.
Reunión:
Congreso; Fourth Latin American Meeting on Biological Inorganic Chemistry (IV LABIC). Fifth Workshop on Bioinorganic Chemistry (V WOQUIBIO).; 2014
Institución organizadora:
Society of Biological Inorganic Chemistry (SBIC)
Resumen:
In this communication we report the synthesis and structural characterization of a new coordination complex of copper(II) and telmisartan, its antihypertensive, cytotoxic, antibacterial and antifungal effects. The octanuclear complex CuTlm defines the inner bond of hydrophobic channels forming molecular nanometer tubes that extends through the crystal. Complexation of the antihypertensive medication generates beneficial properties such as enhancement of the antioxidant activity, cytotoxic behavior against lung and prostate cancer, preservation of the original pharmaceutical properties and antibacterial effect against S. aureus.
