Antimicrobial properties of the ternary Zn(II) complex with sulfadiazine and 2,2'-bipyridine as ligands

JUAN J. MARTÍNEZ MEDINA; DANA B. FALKIEVICH; CRISTIAN VILLA PÉREZ; DELIA B. SORIA

Virtual

Congreso; 6ta Reunión Internacional de Ciencias Farmacéuticas; 2021

Universidad Nacional de Córdoba y Universidad Nacional de Rosario

Sulfadiazine (SDZ) is a bacteriostatic sulfonamide which inhibits the enzymatic activity of dihydropteroate synthetase. 2,2′-bipyridine (bipy) is a N,N′-bidentate ligand widely used as a coligand with a broad antimicrobial spectrum. The antimicrobial profile of these compounds could be enhanced upon complexation with an antiseptic metal like zinc. The aim of this work was to evaluate the antimicrobial properties of the Zn(II)SDZbipy complex. The complex showed MIC values from 125 to 500 μg/mL (clinically relevant) against Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Candida albicans, Candida glabrata and Candida krusei. Complexation also enhanced the antimicrobial activity of SDZ against Escherichia coli, and the Staphylococcus and Candida strains mentioned above.