INVESTIGADORES
PÉREZ Pedro Antonio
congresos y reuniones científicas
Título:
Radioinmmunotherapy treatment planning by means of dedicated Monte Carlo simulations based on patient anatomical and functional images.
Autor/es:
P. PÉREZ; F. MALANO; M. VALENTE
Lugar:
Córdoba
Reunión:
Congreso; 3er Congreso de Radioquimioterapia y Braquiterapia - 6ta Jornada de Física Médica; 2011
Institución organizadora:
Fundación Marie Curie
Resumen:
Different radionuclides have proved to be appropieated for radioinmunotherapy. Dosimetric performance of each radionuclide has to be carefully studied and characterized before any treatment. These studies can help to optimize both the damage to the tumor to be irradiated and minimize the probability of complications in sensitive organs close to the tumor.It would be desirable to introduce patient specific images during the planning and calculations process in order to improve and optimize dosimetric performance. In this sense, both the tumor activity and thepatient anatomy should be incorporated. Metabolic imaging techniques have shown to be valuable non-invasive and reliable diagnostic methodologies. Besides, X-Ray computed tomography can be used to generate 3D-images with information about patient anatomical  structures. Nowadays, dual imaging techniques like PET-CT or SPECT-CT are capable to suitably combine both functional and anatomical imaging methods even assessing accurate matching between them.This work presents a method capable of performing dose distribution for nuclear medicine dosimetry by means of Monte Carlo methods using specific-patient images in order to assess 3D-dose calculation aimedto treatment planning. The developed calculation system allows to perform simulation concerning different types of radionuclides including gamma, beta + and beta ? isotopes. The 3D-dose distribution is achievedby means of suitable voxelization methods. The feasibility, reliability and accuracy of the developed method has been carefully investigated by means of comparisons with alternative dosimetric systems. As example,scaled dose point kernels (sDPK) have been considered for preliminary validation. The obtained results suggests a promising performance.